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What are the long term side effects of methotrexate? If you are using methotrexate long term, a liver biopsy is usually recommended. Methotrexate use has rarely caused serious (sometimes fatal) side effects, such as lung problems, lung infections (Pneumocystis jiroveci pneumonia), skin reactions, diarrhea, and mouth sores (ulcerative stomatitis).
Can you skip a week of methotrexate? Methotrexate once-weekly: doses should normally be taken on the same day each week (11,12). If a dose is missed, it can be taken as soon as it is remembered if this is within two days. A double dose should not be taken to make up for a missed dose (11).
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